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Title   원발성 간암 환자에서 간동맥내 Cisplatin 주입요법의 치료 효과 ( Therapeautic Effect of Hepatic Arterial Infusion of Cisplatin in Primary Hepatocellular Carcinoma )
Publicationinfo   1993 Jan; 025(06): 865-873.
Key_word   Hepatocellular carcinoma, Chemoembolization, Cisplatin
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Abstract   Hepatocellular carcinoma is one of the most common malignant neoplasms in Korea and its prognosis with conventional treatment is poor(about l-4 months). Although the tumor is small, surgical resection is often not indicated because of a preexisting advanced cirrhosis, multifocality, or site of the lesions. Recently transarterial embolization and chemoembolization are used for treatment of unresectable HCC. This study was undertaken to assess the therapeutic efficacy of hepatic arterial infusion of cisplatin alone(Group l) or cisplatin combined with lipiodol or lipiodol and ADR(Group II). We analized the response rate, survival rate, and side effects according to the therapeutic modality. The response rates were 14%, 21% in group I, II and there was no significant difference between two groups. The survival rate at 6 months, 1 year for all 21 patients was 71%, 33% respectively and there was no significant dif ference according to therapeutic modalities. Adverse reactions from treatment included nau- sea, vomiting, fever, abdominal pain and elevation of transaminases. These were mild and tolerated by patients. In conclusion, these results were not better than other chemoembolization with various chemotherapeutic agent, but the side effects were tolerated by patients and further study will be needed.
저 자   조재용(Jin Hyuk Choi),최진혁(Jin Hyuk Choi),유내춘(Nae Chun Yoo),임호영(Ho Yeong Lim),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),이종태(Jong Tae Lee),김병수(Byung Soo Kim)